Comparative evaluation of reference-free transcriptomic deconvolution highlights the importance of biological validation in astrocytes across Alzheimer’s disease

IntroductionAstrocytes are central regulators of neuronal energy metabolism and redox homeostasis—processes that become progressively disrupted across the Alzheimer’s disease (AD) continuum. However, bulk transcriptomic data obscure cell-type–specific signals, and existing reference-free deconvoluti...

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Detalhes bibliográficos

Principais autores:	Laura Rodríguez-Millan, Andrea Angarita-Rodríguez, Viviana Vargas-López, Andrés Pinzón, Estefania Tarifeño-Saldivia, Janneth González
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-07-01
coleção:	Frontiers in Bioinformatics
Assuntos:	Alzheimer’s disease astrocytes bulk RNA-seq CDSeq cognitive impairment DECODER
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fbinf.2026.1858866/full
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