Comparative evaluation of reference-free transcriptomic deconvolution highlights the importance of biological validation in astrocytes across Alzheimer’s disease

IntroductionAstrocytes are central regulators of neuronal energy metabolism and redox homeostasis—processes that become progressively disrupted across the Alzheimer’s disease (AD) continuum. However, bulk transcriptomic data obscure cell-type–specific signals, and existing reference-free deconvoluti...

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Bibliographic Details

Main Authors:	Laura Rodríguez-Millan, Andrea Angarita-Rodríguez, Viviana Vargas-López, Andrés Pinzón, Estefania Tarifeño-Saldivia, Janneth González
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-07-01
Series:	Frontiers in Bioinformatics
Subjects:	Alzheimer’s disease astrocytes bulk RNA-seq CDSeq cognitive impairment DECODER
Online Access:	https://www.frontiersin.org/articles/10.3389/fbinf.2026.1858866/full
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