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Role of DNA Methylation in Modulating Transcription Factor Occupancy

Although DNA methylation is commonly invoked as a mechanism for transcriptional repression, the extent to which it actively silences transcription factor (TF) occupancy sites in vivo is unknown. To study the role of DNA methylation in the active modulation of TF binding, we quantified the effect of...

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Principais autores: Matthew T. Maurano, Hao Wang, Sam John, Anthony Shafer, Theresa Canfield, Kristen Lee, John A. Stamatoyannopoulos
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015-08-01
coleção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124715007640
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