Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors

The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor–pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodiv...

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Egile Nagusiak:	Xinhong Li, Yijie Xu, Wei Li, Jinjing Che, Xu Zhao, Ruyuan Cao, Xingzhou Li, Song Li
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2023-02-01
Saila:	Molecules
Gaiak:	influenza virus antiviral PB2 inhibitors 2,3-dihydro-imidazopyridine molecular dynamics MM/PBSA
Sarrera elektronikoa:	https://www.mdpi.com/1420-3049/28/4/1849
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