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CETP inhibitor evacetrapib enters mouse brain tissue

High levels of plasma cholesterol, especially high levels of low-density lipoprotein cholesterol (LDL-C), have been associated with an increased risk of Alzheimer’s disease. The cholesteryl ester transfer protein (CETP) in plasma distributes cholesteryl esters between lipoproteins and increases LDL-...

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Autori principali: Jasmine Phénix, Jonathan Côté, Denis Dieme, Sherilyn J. Recinto, Felix Oestereich, Sasen Efrem, Sami Haddad, Michèle Bouchard, Lisa Marie Munter
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2023-07-01
Serie:Frontiers in Pharmacology
Soggetti:
cholesterol
evacetrapib
brain
cholesteryl ester transfer protein (CETP)
Alzheimer’s disease
PBPK model
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2023.1171937/full
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