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Identification of Anti-Mycobacterium and Anti-Legionella Compounds With Potential Distinctive Structural Scaffolds From an HD-PBL Using Phenotypic Screens in Amoebae Host Models

Tubercular Mycobacteria and Legionella pneumophila are the causative agents of potentially fatal respiratory diseases due to their intrinsic pathogenesis but also due to the emergence of antibiotic resistance that limits treatment options. The aim of our study was to explore the antimicrobial activi...

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Principais autores: Nabil Hanna, Sébastien Kicka, Gianpaolo Chiriano, Christopher Harrison, Hajer Ouertatani Sakouhi, Valentin Trofimov, Agata Kranjc, Jahn Nitschke, Marco Pagni, Pierre Cosson, Hubert Hilbi, Leonardo Scapozza, Thierry Soldati
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-02-01
Serier:Frontiers in Microbiology
Fag:
Mycobacterium
Legionella
anti-infective
ChemGPS
amoebae
Online adgang:https://www.frontiersin.org/article/10.3389/fmicb.2020.00266/full
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