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Footprint of pancreas infiltrating and circulating immune cells throughout type 1 diabetes development

IntroductionType 1 diabetes (T1D) is defined by immune cell infiltration of the pancreas, in particular the islets of Langerhans, referred to as insulitis, which is especially prominent during the early disease stages in association with decreased beta cell mass. An in-depth understanding of the dyn...

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Main Authors: Ylke Bruggeman, Pieter-Jan Martens, Gabriele Sassi, Marijke Viaene, Clive H. Wasserfall, Chantal Mathieu, Conny Gysemans
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Endocrinology
Subjects:
type 1 diabetes
immunodynamics
NOD mouse model
single cell RNA sequencing
pancreas
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1275316/full
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