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Prediction of drug-drug interactions in clozapine combination therapy based on physiologically based pharmacokinetic model

Objective·To develop physiologically based pharmacokinetic (PBPK) models specifically designed for the Chinese population by utilizing the combination of clozapine and fluvoxamine as a case, and predict the drug-drug interaction (DDI) associated with the combination medication of clozapine, ultimate...

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Principais autores: MOU Fan, HUANG Zhiwei, CHENG Yu, ZHAO Xue, LI Huafang, YU Shunying
Formato: Artigo
Idioma:Chinês
Publicado em: Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science) 2024-11-01
coleção:Shanghai Jiaotong Daxue xuebao. Yixue ban
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Acesso em linha:https://xuebao.shsmu.edu.cn/article/2024/1674-8115/1674-8115-2024-44-11-1414.shtml
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