Genetic diversity of Collaborative Cross mice implicates FFAR3 as a target for ILC2 anti-inflammatory reprogramming

Abstract Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative tr...

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Detalles Bibliográficos

Principais autores:	Mark Rusznak, Shinji Toki, Yajing Hao, Marc J. C. Todd, Liddy Malone, Julia F. Goodhead, Catherine DuPuy, Weisong Zhou, Dominique Babin, Christian M. Warren, Masako Abney, Matthew T. Stier, Christopher M. Thomas, Jing Li, Justin Jacobse, Andrew P. Pahnke, Mark I. Petrovic, Jacqueline-Yvonne Cephus, Shelby N. Kuehnle, M. Wade Calcutt, Allison E. Norlander, Fang Yan, Jeremy A. Goettel, Darla R. Miller, Rachel M. Lynch, Daniel P. Cook, Dawn C. Newcomb, Fei Zou, R. Stokes Peebles
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2026-01-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-025-67813-2
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