4-Methoxy Sulfonyl Paeonol Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis by Blocking the TGF-β1/Smad, PDGF-BB/MAPK and Akt Signaling Pathways

Liver fibrosis initiates the progression of cirrhosis, and, finally, hepatocellular carcinoma (HCC). The increased proliferation and activation of hepatic stellate cells (HSCs) are crucial for hepatic fibrogenesis. Paeonol is the major vigorous component of Cortex Moutan, a traditional herbal medici...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yi-Jen Liao, Yuan-Hsi Wang, Chao-Lien Liu, Cheng-Chieh Fang, Ming-Hua Hsu, Fat-Moon Suk
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-08-01
Schriftenreihe:	Applied Sciences
Schlagworte:	hepatic stellate cells (HSCs) liver fibrosis paeonol derivative
Online-Zugang:	https://www.mdpi.com/2076-3417/10/17/5941
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