Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts

Abstract Background Sos1 and Sos2 are guanine-nucleotide exchange factors for Ras and Rac small GTPases, which are involved in a wide range of cellular responses including proliferation and migration. We have previously shown that Sos1 and Sos2 have different effects on cell migration, but the under...

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Hauptverfasser:	Pilar Liceras-Boillos, Rósula Garcia-Navas, Clara Llorente-González, L. Francisco Lorenzo-Martin, Luis Luna-Ramírez, Rocío Fuentes-Mateos, Nuria Calzada, Francisco M. Vega, Mark R. Holt, Anne J. Ridley, Xose R. Bustelo, Miguel Vicente-Manzanares, Eugenio Santos, Fernando C. Baltanás
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-03-01
Schriftenreihe:	Cell Communication and Signaling
Schlagworte:	Sos1 Sos2 RasGEF Ras Rac Migration
Online-Zugang:	https://doi.org/10.1186/s12964-025-02122-1
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