A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary

Background & Aims: GATA family transcription factors are somatically variable (SV) in esophageal adenocarcinomas (EAC) and inducible by simulated reflux. Our study examines the mechanisms whereby GATA family members (GATA4, GATA6, and the atypical TRPS-1) influence oncogenesis during the Barrett...

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Principais autores:	Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan
格式:	Artigo
语言:	Inglês
出版:	Elsevier 2025-01-01
丛编:	Cellular and Molecular Gastroenterology and Hepatology
主题:	High-Grade Dysplasia Esophageal Adenocarcinoma Gastroesophageal Reflux Disease Organ-On-A-Chip Barrett’s Esophagus
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2352345X25000931
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