A Reflux Linked GATA Factor Fulcrum Dictates Lineage Commitment Through GPRC5B During the Esophageal Dysplastic TransitionSummary

Background & Aims: GATA family transcription factors are somatically variable (SV) in esophageal adenocarcinomas (EAC) and inducible by simulated reflux. Our study examines the mechanisms whereby GATA family members (GATA4, GATA6, and the atypical TRPS-1) influence oncogenesis during the Barrett...

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Príomhchruthaitheoirí:	Omar Abuhussein, Sara Hosseini-Farahabadi, Corina Stewart, Stephane Flibotte, Alireza Heravi-Moussavi, David Farnell, David Schaeffer, Fergal Donnellan, Frank McKeon, Wa Xian, Dermot Kelleher, Shane Patrick Duggan
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	Elsevier 2025-01-01
Sraith:	Cellular and Molecular Gastroenterology and Hepatology
Ábhair:	High-Grade Dysplasia Esophageal Adenocarcinoma Gastroesophageal Reflux Disease Organ-On-A-Chip Barrett’s Esophagus
Rochtain ar líne:	http://www.sciencedirect.com/science/article/pii/S2352345X25000931
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