In Vitro Stability and Preclinical Safety Evaluation of High-Dose Intravitreal Topotecan in Rabbits: Impact of Dose and Concentration

Purpose: To assess the stability of concentrated solutions of topotecan and the ocular and systemic safety of administering repeated very high doses of intravitreal (IVi) topotecan in rabbits. Design: Experimental study. Subjects: Twenty four nontumor-bearing New Zealand White rabbits. Main Outcome...

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主要な著者:	María J. Del Sole, PhD, Pablo Nejamkin, PhD, Javier Opezzo, PhD, Debora Chan, PhD, Andrés Farall, PhD, Gabriela Lamas, MD, Fabiana Lubieniecki, MD, David H. Abramson, MD, Paula Schaiquevich, PhD
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-01-01
シリーズ:	Ophthalmology Science
主題:	Intravitreal injections Rabbit Retinoblastoma Safety Topotecan
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2666914525002611
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