In Vitro Stability and Preclinical Safety Evaluation of High-Dose Intravitreal Topotecan in Rabbits: Impact of Dose and Concentration

Purpose: To assess the stability of concentrated solutions of topotecan and the ocular and systemic safety of administering repeated very high doses of intravitreal (IVi) topotecan in rabbits. Design: Experimental study. Subjects: Twenty four nontumor-bearing New Zealand White rabbits. Main Outcome...

Celý popis

Podrobná bibliografie

Hlavní autoři:	María J. Del Sole, PhD, Pablo Nejamkin, PhD, Javier Opezzo, PhD, Debora Chan, PhD, Andrés Farall, PhD, Gabriela Lamas, MD, Fabiana Lubieniecki, MD, David H. Abramson, MD, Paula Schaiquevich, PhD
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-01-01
Edice:	Ophthalmology Science
Témata:	Intravitreal injections Rabbit Retinoblastoma Safety Topotecan
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666914525002611
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!