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Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats.

Palmitoylethanolamide (PEA) has antinflammatory and antinociceptive properties widely exploited in veterinary and human medicine, despite its poor pharmacokinetics. Looking for prodrugs that could progressively release PEA to maintain effective plasma concentrations, we prepared carbonates, esters a...

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Ngā kaituhi matua: Federica Vacondio, Michele Bassi, Claudia Silva, Riccardo Castelli, Caterina Carmi, Laura Scalvini, Alessio Lodola, Valentina Vivo, Lisa Flammini, Elisabetta Barocelli, Marco Mor, Silvia Rivara
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Public Library of Science (PLoS) 2015-01-01
Rangatū:PLoS ONE
Urunga tuihono:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0128699&type=printable
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