Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats.

Palmitoylethanolamide (PEA) has antinflammatory and antinociceptive properties widely exploited in veterinary and human medicine, despite its poor pharmacokinetics. Looking for prodrugs that could progressively release PEA to maintain effective plasma concentrations, we prepared carbonates, esters a...

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主要な著者:	Federica Vacondio, Michele Bassi, Claudia Silva, Riccardo Castelli, Caterina Carmi, Laura Scalvini, Alessio Lodola, Valentina Vivo, Lisa Flammini, Elisabetta Barocelli, Marco Mor, Silvia Rivara
フォーマット:	Artigo
言語:	Inglês
出版事項:	Public Library of Science (PLoS) 2015-01-01
シリーズ:	PLoS ONE
オンライン･アクセス:	https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0128699&type=printable
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