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Estrogen Receptor 1 Inhibition of Wnt/β-Catenin Signaling Contributes to Sex Differences in Hepatocarcinogenesis

BackgroundHepatocellular Carcinoma (HCC) is a sexually dimorphic cancer, with female sex being independently protective against HCC incidence and progression. The aim of our study was to understand the mechanism of estrogen receptor signaling in driving sex differences in hepatocarcinogenesis.Method...

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Principais autores: Mamatha Bhat, Elisa Pasini, Chiara Pastrello, Marc Angeli, Cristina Baciu, Mark Abovsky, Angella Coffee, Oyedele Adeyi, Max Kotlyar, Igor Jurisica
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021-11-01
Serier:Frontiers in Oncology
Fag:
estrogen
hepatocellular carcinoma
high-throughput
network analysis
Wnt/b-catenin
ESR1
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2021.777834/full
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