H3K4me3 mediates the NF-κB p50 homodimer binding to the pdcd1 promoter to activate PD-1 transcription in T cells

PD-1 is a co-repressive receptor that curbs T cell activation and thereby serves as a protection mechanism against autoimmunity under physiological conditions. Under pathological conditions, tumor cells express PD-L1 as an adaptive resistant mechanism to suppress PD-1+ T cells to evade host immunosu...

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Podrobná bibliografie

Hlavní autoři:	Priscilla S. Redd, Chunwan Lu, John D. Klement, Mohammed L. Ibrahim, Gang Zhou, Takumi Kumai, Esteban Celis, Kebin Liu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2018-09-01
Edice:	OncoImmunology
Témata:	pd-1 t cells nf-κb h3k4me3 p50
On-line přístup:	http://dx.doi.org/10.1080/2162402X.2018.1483302
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