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Quaking but not parkin is the major tumor suppressor in 6q deleted region in glioblastoma

Glioblastoma (GBM) is a high-grade, aggressive brain tumor with dismal median survival time of 15 months. Chromosome 6q (Ch6q) is a hotspot of genomic alterations, which is commonly deleted or hyper-methylated in GBM. Two neighboring genes in this region, QKI and PRKN have been appointed as tumor su...

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Hlavní autoři: Fatma Betul Aksoy Yasar, Takashi Shingu, Daniel B. Zamler, Mohammad Fayyad Zaman, Derek Lin Chien, Qiang Zhang, Jiangong Ren, Jian Hu
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2022-08-01
Edice:Frontiers in Cell and Developmental Biology
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On-line přístup:https://www.frontiersin.org/articles/10.3389/fcell.2022.931387/full
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