The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export

Summary: Fanconi anemia (FA) is characterized by congenital abnormalities, bone marrow failure, and cancer susceptibility. The central FA protein complex FANCI/FANCD2 (ID2) is activated by monoubiquitination and recruits DNA repair proteins for interstrand crosslink (ICL) repair and replication fork...

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Principais autores:	Anne Olazabal-Herrero, Boxue He, Youngho Kwon, Abhishek K. Gupta, Arijit Dutta, Yuxin Huang, Prajwal Boddu, Zhuobin Liang, Fengshan Liang, Yaqun Teng, Li Lan, Xiaoyong Chen, Huadong Pei, Manoj M. Pillai, Patrick Sung, Gary M. Kupfer
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-01-01
Series:	Cell Reports
Assuntos:	CP: Molecular biology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124723016224
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