Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma

Abstract Background Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness...

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Autori principali:	Jiayun Wei, Jia Yao, Chendong Yang, Yongcui Mao, Dan Zhu, Ye Xie, Pinyan Liu, Mengchao Yan, Longfei Ren, Yan Lin, Qiuxia Zheng, Xun Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-12-01
Serie:	Journal of Translational Medicine
Soggetti:	Matrix stiffness Cancer cell stemness Heterogeneity Hepatocellular carcinoma Yes-associated protein
Accesso online:	https://doi.org/10.1186/s12967-022-03778-w
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