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Structural constraints identified with covariation analysis in ribosomal RNA.

Covariation analysis is used to identify those positions with similar patterns of sequence variation in an alignment of RNA sequences. These constraints on the evolution of two positions are usually associated with a base pair in a helix. While mutual information (MI) has been used to accurately pre...

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Autori principali: Lei Shang, Weijia Xu, Stuart Ozer, Robin R Gutell
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science (PLoS) 2012-01-01
Serie:PLoS ONE
Accesso online:http://europepmc.org/articles/PMC3378556?pdf=render
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