NVP-BEZ235 (Dactolisib) Has Protective Effects in a Transgenic Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is a neurodegenerative disease and the main cause of dementia. Its major symptom is memory loss, which is a result of neuronal cell death, which is accompanied by neuroinflammation. Some studies indicate the overactivation of the phosphatidylinositol 3-kinase (PI3K)/protein...

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Detalhes bibliográficos

Principais autores:	Paula Maria Quaglio Bellozi, Giovanni Freitas Gomes, Leonardo Rossi de Oliveira, Isabella Guimarães Olmo, Érica Leandro Marciano Vieira, Fabíola Mara Ribeiro, Bernd L. Fiebich, Antônio Carlos Pinheiro de Oliveira
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-11-01
Colecção:	Frontiers in Pharmacology
Assuntos:	Alzheimer’s disease dactolisib NVP-BEZ235 neurodegeneration neuroinflammation PI3K
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fphar.2019.01345/full
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