Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
<p>Abstract</p> <p>Protein kinases of the MARK family phosphorylate tau protein in its repeat domain and thereby regulate its affinity for microtubules and affect the aggregation of tau into Alzheimer paired helical filaments. We are searching for low molecular weight compounds to interfere with the...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BMC
2008-12-01
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| Edice: | BMC Neuroscience |
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