Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Abstract Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly correlated with stage and grade in several human c...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2023-08-01
Sarja:	Journal of Experimental & Clinical Cancer Research
Aiheet:	Autotaxin Lysophosphatidic acid Gastrointestinal cancers
Linkit:	https://doi.org/10.1186/s13046-023-02780-4
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