Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models
Abstract Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly correlated with stage and grade in several human c...
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| Glavni autori: | , , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
BMC
2023-08-01
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| Serija: | Journal of Experimental & Clinical Cancer Research |
| Teme: | |
| Online pristup: | https://doi.org/10.1186/s13046-023-02780-4 |
| Oznake: |
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