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Antiproliferative Activity and Molecular Docking of Novel Double-Modified Colchicine Derivatives

Microtubules are tubulin polymer structures, which are indispensable for cell growth and division. Its constituent protein β-tubulin has been a common drug target for various diseases including cancer. Colchicine has been used to treat gout, but it has also been an investigational anticancer ag...

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Principais autores: Urszula Majcher, Greta Klejborowska, Mahshad Moshari, Ewa Maj, Joanna Wietrzyk, Franz Bartl, Jack A. Tuszynski, Adam Huczyński
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2018-11-01
Serier:Cells
Fag:
colchicine binding site inhibitor
β-tubulin affinity
antimitotic agent
antiproliferative activity
thiocolchicine
Online adgang:https://www.mdpi.com/2073-4409/7/11/192
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