Dual-functioning Targeted ADAM17 Blocker CD16 (TAB16) mediates selective ADAM17 inhibition in NK cells and engages overexpressed ADAM17 in tumor cells to induce cytotoxicity

IntroductionNatural killer (NK) cells are innate lymphocytes that kill tumor cells by natural cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC). Human NK cells mediate the latter process exclusively by the IgG Fc receptor CD16 (FcγRIIIA). Cell surface levels of this activating re...

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Autori principali:	Kate J. Dixon, Robert Hullsiek, Sam Wang, Ryan R. Friess, Anders W. Matson, Yvette Soignier, Alexander J. Lenvik, Jianming Wu, Geoffrey T. Hart, Martin Felices, Bruce Walcheck
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Immunology
Soggetti:	ADAM17 (a disintegrin and metalloprotease 17) ADCC - antibody-dependent cellular cytotoxicity immunotherapy natural killer (NK) cell ovarian cancer
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1714022/full
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