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iPSC-derived NK cells expressing high-affinity IgG Fc receptor fusion CD64/16A to mediate flexible, multi-tumor antigen targeting for lymphoma

IntroductionNK cells can mediate tumor cell killing by natural cytotoxicity and by antibody-dependent cell-mediated cytotoxicity (ADCC), an anti-tumor mechanism mediated through the IgG Fc receptor CD16A (FcγRIIIA). CD16A polymorphisms conferring increased affinity for IgG positively correlate with...

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Principais autores: Kate J. Dixon, Kristin M. Snyder, Melissa Khaw, Robert Hullsiek, Zachary B. Davis, Anders W. Matson, Soheila Shirinbak, Bryan Hancock, Ryan Bjordahl, Martin Hosking, Jeffrey S. Miller, Bahram Valamehr, Jianming Wu, Bruce Walcheck
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-07-01
coleção:Frontiers in Immunology
Assuntos:
natural killer (NK) cell
antibody
ADCC - antibody-dependent cellular cytotoxicity
immunotherapy
cancer
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1407567/full
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