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Nutraceutical Molecules Slow Down Retinal Degeneration, in Tvrm4 Mice a Model of Retinitis Pigmentosa, by Genetic Modulation of Anti-oxidant Pathway

Rhodopsin (RHO) mutations are responsible for 25–40% of the dominant cases of retinitis pigmentosa (RP) with different severity and progression rates. The Tvrm4 mice, heterozygous for an I307N dominant mutation of RHO, display a normal retinal phenotype when raised in ambient light conditions, but u...

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Principais autores: Ilaria Piano, Francesca Corsi, Beatrice Polini, Claudia Gargini
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-04-01
Serier:Frontiers in Neuroscience
Fag:
nutraceutical treatment
photoreceptors degeneration
genetic modulation
oxidative stress
retinitis pigmentosa
Online adgang:https://www.frontiersin.org/articles/10.3389/fnins.2022.868750/full
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