A spatially specified systems pharmacology therapy for axonal recovery after injury

There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the...

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Auteurs principaux:	Mustafa M. Siddiq, Nicholas P. Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A. Toro, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher P. Cardozo, Christopher L. Passaglia, Ravi Iyengar
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2023-09-01
Collection:	Frontiers in Pharmacology
Sujets:	microfluidic chambers retinal ganglion cell iDISCO electrophysiology electroretinogram
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fphar.2023.1225759/full
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