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A spatially specified systems pharmacology therapy for axonal recovery after injury

There are no known drugs or drug combinations that promote substantial central nervous system axonal regeneration after injury. We used systems pharmacology approaches to model pathways underlying axonal growth and identify a four-drug combination that regulates multiple subcellular processes in the...

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Principais autores: Mustafa M. Siddiq, Nicholas P. Johnson, Yana Zorina, Arjun Singh Yadaw, Carlos A. Toro, Jens Hansen, Vera Rabinovich, Sarah M. Gregorich, Yuguang Xiong, Rosa E. Tolentino, Sari S. Hannila, Ehud Kaplan, Robert D. Blitzer, Marie T. Filbin, Christopher P. Cardozo, Christopher L. Passaglia, Ravi Iyengar
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-09-01
coleção:Frontiers in Pharmacology
Assuntos:
microfluidic chambers
retinal ganglion cell
iDISCO
electrophysiology
electroretinogram
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2023.1225759/full
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