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Reduced mGluR5 Activity Modulates Mitochondrial Function

The metabotropic glutamate receptor 5 (mGluR5) is an essential modulator of synaptic plasticity, learning and memory; whereas in pathological conditions, it is an acknowledged therapeutic target that has been implicated in multiple brain disorders. Despite robust pre-clinical data, mGluR5 antagonist...

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Principais autores: Miguel A. Gonzalez-Lozano, Joke Wortel, Rolinka J. van der Loo, Jan R. T. van Weering, August B. Smit, Ka Wan Li
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-06-01
Serier:Cells
Fag:
proteomics
mGluR5
mitochondria
mass spectrometry
synapse
CTEP
Online adgang:https://www.mdpi.com/2073-4409/10/6/1375
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