Exploring novel ligands for mGluR5: Design, computational analysis, and protein-ligand interaction studies
Abstracts: Metabotropic glutamate receptors (mGluRs) are G-protein-coupled receptors activated by glutamate. A series of 90 novel compounds have been assessed as mGluR5 receptor antagonists. These compounds, selected post-ADMET filtering according to Lipinski's rule of five, represent structurally i...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2024-12-01
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| Serie: | Chemical Physics Impact |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2667022424002354 |
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