Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
ABSTRACT There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic antibodies with significantly e...
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| Hlavní autor: | |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Oxford University Press
2017-04-01
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| Edice: | Protein & Cell |
| Témata: | |
| On-line přístup: | http://link.springer.com/article/10.1007/s13238-017-0408-4 |
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