Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
ABSTRACT There are many factors that can influence the pharmacokinetics (PK) of a mAb or Fc-fusion molecule with the primary determinant being FcRn-mediated recycling. Through Fab or Fc engineering, IgG-FcRn interaction can be used to generate a variety of therapeutic antibodies with significantly e...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2017-04-01
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| Schriftenreihe: | Protein & Cell |
| Schlagworte: | |
| Online-Zugang: | http://link.springer.com/article/10.1007/s13238-017-0408-4 |
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