Plasmodium falciparum DHFR and DHPS Mutations Are Associated With HIV-1 Co-Infection and a Novel DHPS Mutation I504T Is Identified in Western Kenya

Antifolate resistance is significant in Kenya and presumed to result from extensive use and cross-resistance between antifolate antimalarials and antibiotics, including cotrimoxazole/Bactrim used for HIV-1 chemotherapy. However, little is known about antifolate-resistant malaria in the context of ne...

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Principais autores:	Brandi K. Torrevillas, Sarah M. Garrison, Alexander J. McKeeken, Dharmeshkumar Patel, James T. Van Leuven, Nathaniel I. Dizon, Karina I. Rivas, Nicholas J. Hathaway, Jeffrey A. Bailey, John N. Waitumbi, Carolyne M. Kifude, Janet Oyieko, V. Ann Stewart, Shirley Luckhart
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-11-01
Colecção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	antimalarial drug resistance antifolate therapy HIV-1 asymptomatic malaria targeted deep sequencing complexity of infection
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2020.600112/full
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