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Herpes Simplex Virus 1 Tegument Protein UL46 Inhibits TANK-Binding Kinase 1-Mediated Signaling

ABSTRACT TANK-binding kinase 1 (TBK1) is a key component of the antiviral immunity signaling pathway. It activates downstream interferon regulatory factor 3 (IRF3) and subsequent type I interferon (IFN-I) production. Herpes simplex virus type 1 (HSV-1) can antagonize host antiviral immune responses...

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Autori principali: Hongjuan You, Sisilia Zheng, Zhiming Huang, Yingying Lin, Qingtang Shen, Chunfu Zheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019-06-01
Serie:mBio
Soggetti:
HSV-1
IRF3
TBK1
UL46
type I IFN
Accesso online:https://journals.asm.org/doi/10.1128/mBio.00919-19
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