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REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study

Brain-derived neurotrophic factor (BDNF), a neurotrophin widely expressed in the central nervous system, exhibits important effects on neural plasticity. BDNF has been implicated in the mechanism of action of ketamine, a N-methyl-d-aspartic acid receptor (NMDAR) antagonist with rapid anti-depressant...

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Principais autores: Sara De Martin, Daniela Gabbia, Franco Folli, Francesco Bifari, Paolo Fiorina, Nicola Ferri, Stephen Stahl, Charles E. Inturrisi, Marco Pappagallo, Sergio Traversa, Paolo L. Manfredi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-04-01
coleção:Frontiers in Pharmacology
Assuntos:
esmethadone
BDNF
depression
clinical trial
NMDAR
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2021.671859/full
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