Noninvasive Assessment of β‐Secretase Activity Through Click Chemistry‐Mediated Enrichment of Neuronal Extracellular Vesicles to Detect Alzheimer's Disease

Abstract Alzheimer's disease (AD), the most prevalent type of dementia, is characterized by a biological process that begins with the development of AD neuropathologic change (ADNPC) while individuals remain asymptomatic. A key molecular hallmark of ADNPC is the accumulation of amyloid‐β plaques. β‐...

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Autores principales:	Hyoyong Kim, Junseok Lee, Audrey Qian, You‐Ren Ji, Ryan Zhang, Qixin Hu, Christopher Kazu Williams, Han‐Yu Chuang, Matthew D. Smalley, Yaya Xu, Liang Gao, Mary C. Mayo, Ting Zhang, Edwin M. Posadas, Zaldy S. Tan, Harry V. Vinters, Keith Vossel, Shino Magaki, Yazhen Zhu, Hsian‐Rong Tseng
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Wiley 2025-07-01
Colección:	Advanced Science
Materias:	Alzheimer's disease liquid biopsy neurodegenerative disease neuronal extracellular vesicle β‐secretase
Acceso en línea:	https://doi.org/10.1002/advs.202415289
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