Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities

Chromosomal aneuploidy and specific gene mutations are recognized early hallmarks of many oncogenic processes. However, the net effect of these abnormalities has generally not been explored. We focused on transient myeloproliferative disorder (TMD) in Down syndrome, which is characteristically assoc...

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Autori principali:	Kimihiko Banno, Sayaka Omori, Katsuya Hirata, Nobutoshi Nawa, Natsuki Nakagawa, Ken Nishimura, Manami Ohtaka, Mahito Nakanishi, Tetsushi Sakuma, Takashi Yamamoto, Tsutomu Toki, Etsuro Ito, Toshiyuki Yamamoto, Chikara Kokubu, Junji Takeda, Hidetoshi Taniguchi, Hitomi Arahori, Kazuko Wada, Yasuji Kitabatake, Keiichi Ozono
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2016-05-01
Serie:	Cell Reports
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124716304442
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