Interplay between DYRK1A dosage and aneuploidy-induced neuropathology in Down syndrome

Abstract A reduction in the number of neurons and an increased susceptibility to apoptosis are one of the characteristic features observed in Down syndrome (DS). However, the multifaceted actions of chromosomal aneuploidy hinder the elucidation of the underlying mechanism. Here, using neurons and as...

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Bibliografiska uppgifter

Huvudupphov:	Toshihiko Nambara, Joo Yeon Lee, Masaki Minami, Soichiro Okamoto, Keiji Kawatani, Haruna Kusakabe, Hidetaka Yoshimatsu, Katsuya Hirata, Kazuto Yoshimi, Tomoji Mashimo, Akira Tanave, Kenta Sumiyama, Keiichi Ozono, Yasuji Kitabatake
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2026-03-01
Serie:	Communications Biology
Länkar:	https://doi.org/10.1038/s42003-026-09902-6
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