Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

Summary: Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1Amut/-) and found that the mutant mice developed liver steatosis spontaneously under t...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Moke Liu, Luna Liu, Honglin Guo, Xiude Fan, Tianbao Liu, Chao Xu, Zhao He, Yongfeng Song, Ling Gao, Shanshan Shao, Jiajun Zhao, Peng Lu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-10-01
Colecção:	iScience
Assuntos:	Molecular physiology Molecular biology Transcriptomics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2589004223020953
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!