Replication of the Mammalian Genome by Replisomes Specific for Euchromatin and Heterochromatin

Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering activation of the ATR kinase and downstream pathway...

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Principais autores:	Jing Zhang, Marina A. Bellani, Jing Huang, Ryan C. James, Durga Pokharel, Julia Gichimu, Himabindu Gali, Grant Stewart, Michael M. Seidman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-08-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	replication stress replisome CMG FANCM DONSON GINS
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2021.729265/full
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