Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes.

We investigated the effects of AMPK on H(2)O(2)-induced premature senescence in primary human keratinocytes. Incubation with 50 µM H(2)O(2) for 2 h resulted in premature senescence with characteristic increases in senescence-associated ß-galactosidase (SA-gal) staining 3 days later and no changes in...

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Bibliografiske detaljer

Principais autores:	Yasuo Ido, Albert Duranton, Fan Lan, Jose M Cacicedo, Tai C Chen, Lionel Breton, Neil B Ruderman
Format:	Artigo
Sprog:	Inglês
Udgivet:	Public Library of Science (PLoS) 2012-01-01
Serier:	PLoS ONE
Online adgang:	http://europepmc.org/articles/PMC3325987?pdf=render
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