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Immunotherapy with biodegradable nanoparticles encapsulating the oligosaccharide galactose-alpha-1,3-galactose enhance immune tolerance against alpha-gal sensitization in a murine model of alpha-gal syndrome

IgE antibodies against the mammalian oligosaccharide allergen galactose-α-1,3-galactose (αGal) can result in a severe allergic disease known as alpha-gal syndrome (AGS). This syndrome, acquired by tick bites that cause αGal sensitization, leads to allergic reactions after ingestion of non-primate ma...

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Principais autores: Michael N. Saunders, Claudia M. Rival, Mahua Mandal, Kayla Cramton, Laila M. Rad, Katarzyna W. Janczak, Laura A. Williams, Amogh R. Angadi, Jessica J. O’Konek, Lonnie D. Shea, Loren D. Erickson
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-08-01
Serier:Frontiers in Allergy
Fag:
nanoparticle
tolerance
IgE sensitization
carbohydrates
galactose-α-1
3-galactose
Online adgang:https://www.frontiersin.org/articles/10.3389/falgy.2024.1437523/full
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