Reprogrammed CD8⁺ T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells

We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8⁺ T-cells could also create a population of immune cells with high antitumor...

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Podrobná bibliografie

Hlavní autoři:	Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Angelina Pakhomova, Natalia Ermakova, Darius Widera, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2023-03-01
Edice:	Medical Sciences Forum
Témata:	reprogrammed spleen CD8<sup>+</sup> T-cells Lewis lung carcinoma cancer stem cell CD8<sup>+</sup> and CD4<sup>+</sup> T-cells antimetastatic activity
On-line přístup:	https://www.mdpi.com/2673-9992/21/1/40
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