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Reprogrammed CD8<sup>+</sup> T-Cells Isolated from the Mouse Spleen Increase the Number of Immune Cells with Antitumor Activity and Decrease the Amount of Cancer Stem Cells

We have developed an approach to reprogramming immune cells by inhibiting the MAPK/ERK pathway through MEKi and the PD-1/PD-L1 immune checkpoint signaling pathway. We hypothesized that reprogramming of spleen CD8<sup>+</sup> T-cells could also create a population of immune cells with high antitumor...

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Kaydedildi:
Asıl Yazarlar: Evgenii G. Skurikhin, Olga Pershina, Mariia Zhukova, Angelina Pakhomova, Natalia Ermakova, Darius Widera, Edgar Pan, Lubov Sandrikina, Lena Kogai, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI AG 2023-03-01
Seri Bilgileri:Medical Sciences Forum
Konular:
reprogrammed spleen CD8<sup>+</sup> T-cells
Lewis lung carcinoma
cancer stem cell
CD8<sup>+</sup> and CD4<sup>+</sup> T-cells
antimetastatic activity
Online Erişim:https://www.mdpi.com/2673-9992/21/1/40
Etiketler: Etiketle
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