Rejuvenating Hyaline Cartilage with Senescence‐Targeting Si‐ADAM19 Delivery for Osteoarthritis Therapy

Abstract Osteoarthritis (OA) is one of the most common joint degenerative diseases without effective treatment, whose pathology is related to the local accumulation of senescent cells (SnCs). However, existing SnCs‐scavenging drugs “senolytics” may lead to the exhaustion of stem and progenitor cells...

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Autori principali:	Jiasheng Wang, Peng Guo, Dongmei Wu, Junzhi Yi, Qi Jiang, Jiajie Hu, Hongwei Ouyang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2025-04-01
Serie:	Advanced Science
Soggetti:	a disintegrin and metalloproteinase 19 (ADAM19) cartilage regeneration cellular senescence osteoarthritis(OA) rejuvenating siRNA delivery
Accesso online:	https://doi.org/10.1002/advs.202414419
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